Annoying, Arduous, Assiduous, Atrocious, Besetting, Biting, Bitter, Bleak, Bothersome, Burdensome, Burning, Careful, Cheerless, Conscientious, Cramping, Cruel, Crushing, Demanding, Deplorable, Depressing, Depressive, Detailed, Diligent, Discomforting, Dismal, Dismaying, Disquieting, Distasteful, Distressing, Disturbing, Dolorous, Dreary, Earnest, Exacting, Exasperating, Excruciating, Forced, Galling, Gnawing, Grave, Grievous, Griping, Grueling, Harassing, Hard, Harrowing, Harsh, Heavy, Hefty, Hurtful, Hurting, Irksome, Irritating, Joyless, Killing, Laborious, Lamentable, Meticulous, Mournful, Moving, Onerous, Oppressive, Painstaking, Pathetic, Piercing, Piteous, Pitiable, Poignant, Pungent, Punishing, Racking, Raw, Regrettable, Rigorous, Rueful, Sad, Saddening, Scrupulous, Sensitive, Severe, Sharp, Shooting, Smarting, Sore, Sorrowful, Spasmodic, Stabbing, Stinging, Strained, Aching, Achy, Acute, Affecting, Aggravating, Strenuous, Tender, Thorough, Thoroughgoing, Throbbing, Tormenting, Torturous, Touching, Tough, Troublesome, Troubling, Trying, Uncomfortable, Unpalatable, Unpleasant, Unsavory, Uphill, Vexatious, Vexing, Wearisome, Woebegone, Woeful, Worrisome, Worrying, Wretched